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MGP001741

Record overview

MGPD IDMGP001741
Gene ID3783
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Gene Symbol KCNN4
SynonymsIK; IK1; SK4; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1;
Alternate namesintermediate conductance calcium-activated potassium channel protein 4; SKCa 4; SKCa4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative Gardos channel; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; small conductance calcium-activated potassium channel 4;
Chromosome19
Map Location19q13.2
SummaryThe protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KCNN4

Proteins

intermediate conductance calcium-activated potassium channel protein 4
Refseq ID:NP_002241
Protein GI:4504859
UniProt ID:O15554
mRNA ID:NM_002250
Length:427
RefSeq Status:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVAL
TGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYM
NTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLA
GKLDALTELLSTALGPRQLPEPSQQSK
 
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