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MGP001741

UniProt Annotations

Entry Information
Gene Namepotassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Protein EntryKCNN4_HUMAN
UniProt IDO15554
SpeciesHuman
Comments
Comment typeDescription
FunctionForms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. {ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614}.
InductionUp-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.
PtmPhosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. {ECO:0000269|PubMed:17157250}.
SimilarityBelongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitHeterotetramer of potassium channel proteins (Probable). Interacts with MTMR6. {ECO:0000269|PubMed:10026195, ECO:0000269|PubMed:15831468, ECO:0000305}.
Tissue SpecificityWidely expressed in non-excitable tissues.
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