MGP Database

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MGP001747

UniProt Annotations

Entry Information
Gene Namepotassium voltage-gated channel, modifier subfamily S, member 3
Protein EntryKCNS3_HUMAN
UniProt IDQ9BQ31
SpeciesHuman
Comments
Comment typeDescription
DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
FunctionPotassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity). {ECO:0000250}.
SimilarityBelongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.
SubunitHeteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity). {ECO:0000250}.
Tissue SpecificityDetected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung. {ECO:0000269|PubMed:22943705}.
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