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MGP001755

UniProt Annotations

Entry Information
Gene Namekiller cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
Protein EntryKI2L1_HUMAN
UniProt IDP43626
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43626-1; Sequence=Displayed; Name=2; IsoId=P43626-2; Sequence=VSP_056314; Note=No experimental confirmation available.;
FunctionReceptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:18604210}.
InteractionP29350:PTPN6; NbExp=4; IntAct=EBI-8684277, EBI-78260;
SimilarityBelongs to the immunoglobulin superfamily. {ECO:0000305}.
SimilarityContains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
SubunitInteracts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. {ECO:0000269|PubMed:18604210}.
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