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MGP001771

Record overview

MGPD IDMGP001771
Gene ID3824
SpeciesHomo sapiens (Human)
Gene Namekiller cell lectin-like receptor subfamily D, member 1
Gene Symbol KLRD1
SynonymsCD94;
Alternate namesnatural killer cells antigen CD94; CD94 antigen; KP43; NK cell receptor;
Chromosome12
Map Location12p13
SummaryNatural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KLRD1

Proteins

natural killer cells antigen CD94 isoform 1
Refseq ID:NP_001107868
Protein GI:167614498
UniProt ID:Q13241
mRNA ID:NM_001114396
Length:179
RefSeq Status:
MAVFKTTLWRLISGTLGIICLSLMATLGILLKNSFTKLSIEPAFTPGPNIELQKDSDCCSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQ
NTDELDFMSSSQQFYWIGLSYSEEHTAWLWENGSALSQYLFPSFETFNTKNCIAYNPNGNALDESCEDKNRYICKQQLI
 
natural killer cells antigen CD94 isoform 1
Refseq ID:NP_002253
Protein GI:4504889
UniProt ID:Q13241
mRNA ID:NM_002262
Length:179
RefSeq Status:
Protein sequence is identical to GI:167614498 (mRNA isoform)
 
natural killer cells antigen CD94 isoform 2
Refseq ID:NP_031360
Protein GI:7669499
UniProt ID:Q13241
mRNA ID:NM_007334
Length:148
RefSeq Status:
MAAFTKLSIEPAFTPGPNIELQKDSDCCSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQNTDELDFMSSSQQFYWIGLSYSEEHTAWLWE
NGSALSQYLFPSFETFNTKNCIAYNPNGNALDESCEDKNRYICKQQLI
 
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