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MGP001785

Record overview

MGPD IDMGP001785
Gene ID3845
SpeciesHomo sapiens (Human)
Gene NameKirsten rat sarcoma viral oncogene homolog
Gene Symbol KRAS
SynonymsNS; NS3; CFC2; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B;
Alternate namesGTPase KRas; K-Ras 2; K-ras p21 protein; PR310 c-K-ras oncogene; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; oncogene KRAS2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog;
Chromosome12
Map Location12p12.1
SummaryThis gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KRAS

Proteins

GTPase KRas isoform a
Refseq ID:NP_203524
Protein GI:15718763
UniProt ID:P01116
mRNA ID:NM_033360
Length:189
RefSeq Status:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
 
mat_peptide: 1..186
product: GTPase KRas
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01116.1)
calculated_mol_wt: 21298
peptide sequence: 
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKC

mat_peptide: 2..186
product: GTPase KRas, N-terminally processed
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01116.1)
calculated_mol_wt: 21167
peptide sequence: 
TEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIK
RVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKC
 
GTPase KRas isoform b
Refseq ID:NP_004976
Protein GI:15718761
UniProt ID:P01116
mRNA ID:NM_004985
Length:188
RefSeq Status:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM
 
mat_peptide: 1..186
product: GTPase KRas
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01116.1)
calculated_mol_wt: 21298
peptide sequence: 
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKC

mat_peptide: 2..186
product: GTPase KRas, N-terminally processed
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01116.1)
calculated_mol_wt: 21167
peptide sequence: 
TEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIK
RVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKC
 
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