MGP Database

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MGP001785

Ontology/Pathway Information

Entrez Gene ID3845
Gene NameKirsten rat sarcoma viral oncogene homolog
Gene Symbol KRAS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0031234 IDA:UniProtKBCextrinsic component of cytoplasmic side of plasma membrane
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0016020 IDA:UniProtKBCmembrane
GO:0045121 IEA:EnsemblCmembrane raft
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005886 TAS:ReactomeCplasma membrane
GO:0019003 IEA:EnsemblFGDP binding
GO:0019002 IEA:EnsemblFGMP binding
GO:0005525 IEA:UniProtKB-KWFGTP binding
GO:0032403 IDA:MGIFprotein complex binding
GO:0030036 IEA:EnsemblPactin cytoskeleton organization
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0019221 IEA:EnsemblPcytokine-mediated signaling pathway
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0060441 IEA:EnsemblPepithelial tube branching involved in lung morphogenesis
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006184 IEA:InterProPGTP catabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0000165 TAS:ReactomePMAPK cascade
GO:0045596 IEA:EnsemblPnegative regulation of cell differentiation
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0010628 IMP:BHF-UCLPpositive regulation of gene expression
GO:0043406 IEA:EnsemblPpositive regulation of MAP kinase activity
GO:0051092 IEA:EnsemblPpositive regulation of NF-kappaB transcription factor activity
GO:0051000 IEA:EnsemblPpositive regulation of nitric-oxide synthase activity
GO:0001934 IMP:BHF-UCLPpositive regulation of protein phosphorylation
GO:0035022 IEA:EnsemblPpositive regulation of Rac protein signal transduction
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0048169 IEA:EnsemblPregulation of long-term neuronal synaptic plasticity
GO:0032228 IEA:EnsemblPregulation of synaptic transmission, GABAergic
GO:0051384 IEA:EnsemblPresponse to glucocorticoid
GO:0051385 IEA:EnsemblPresponse to mineralocorticoid
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0035176 IEA:EnsemblPsocial behavior
GO:0051146 IEA:EnsemblPstriated muscle cell differentiation
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118778Activation of RAS in B cells
REACT_75774Adaptive Immune System
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_12051Cell surface interactions at the vascular wall
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_121096EGFR Transactivation by Gastrin
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_962MEK activation
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12065p38MAPK events
REACT_12005Prolonged ERK activation events
REACT_2077RAF activation
REACT_634RAF/MAP kinase cascade
REACT_614RAF phosphorylates MEK
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_21374SHC-mediated cascade
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_12621Tie2 Signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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