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MGP001803

Record overview

MGPD IDMGP001803
Gene ID3932
SpeciesHomo sapiens (Human)
Gene NameLCK proto-oncogene, Src family tyrosine kinase
Gene Symbol LCK
SynonymsLSK; YT16; IMD22; p56lck; pp58lck;
Alternate namestyrosine-protein kinase Lck; T-lymphocyte specific protein tyrosine kinase p56lck; leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; lymphocyte-specific protein tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase;
Chromosome1
Map Location1p34.3
EC Number2.7.10.2
SummaryThis gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LCK

Proteins

tyrosine-protein kinase Lck
Refseq ID:NP_005347
Protein GI:112789546
UniProt ID:P06239
mRNA ID:NM_005356
Length:509
RefSeq Status:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA
QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFP
GLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA
KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTA
TEGQYQPQP
 
tyrosine-protein kinase Lck
Refseq ID:NP_001036236
Protein GI:112789548
UniProt ID:P06239
mRNA ID:NM_001042771
Length:509
RefSeq Status:
Protein sequence is identical to GI:112789546 (mRNA isoform)
 
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