MGP Database

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MGP001803

Ontology/Pathway Information

Entrez Gene ID3932
Gene NameLCK proto-oncogene, Src family tyrosine kinase
Gene Symbol LCK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005829 TAS:ReactomeCcytosol
GO:0030139 IEA:EnsemblCendocytic vesicle
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0001772 IDA:MGICimmunological synapse
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0000242 IDA:UniProtKBCpericentriolar material
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0003823 IEA:EnsemblFantigen binding
GO:0051117 IPI:UniProtKBFATPase binding
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0042609 IPI:UniProtKBFCD4 receptor binding
GO:0042610 IPI:UniProtKBFCD8 receptor binding
GO:0001948 IPI:UniProtKBFglycoprotein binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0004715 IBA:GO_CentralFnon-membrane spanning protein tyrosine kinase activity
GO:0043548 IPI:UniProtKBFphosphatidylinositol 3-kinase binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0004722 IDA:UniProtKBFprotein serine/threonine phosphatase activity
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0042169 IPI:UniProtKBFSH2 domain binding
GO:0006919 IDA:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007568 IEA:EnsemblPaging
GO:0050853 IBA:GO_CentralPB cell receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0071375 IBA:GO_CentralPcellular response to peptide hormone stimulus
GO:0006882 IEP:UniProtKBPcellular zinc ion homeostasis
GO:0016311 IDA:GOCPdephosphorylation
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0030097 NAS:UniProtKBPhemopoiesis
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0050900 TAS:ReactomePleukocyte migration
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030168 TAS:ReactomePplatelet activation
GO:0045588 IEA:EnsemblPpositive regulation of gamma-delta T cell differentiation
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:2001244 IMP:UniProtKBPpositive regulation of intrinsic apoptotic signaling pathway
GO:0050870 IDA:UniProtKBPpositive regulation of T cell activation
GO:0050862 NAS:UniProtKBPpositive regulation of T cell receptor signaling pathway
GO:0042523 IEA:EnsemblPpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0070474 IEA:EnsemblPpositive regulation of uterine smooth muscle contraction
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0042127 IBA:GO_CentralPregulation of cell proliferation
GO:0050690 TAS:ReactomePregulation of defense response to virus by virus
GO:0051249 NAS:UniProtKBPregulation of lymphocyte activation
GO:0051209 ISS:UniProtKBPrelease of sequestered calcium ion into cytosol
GO:0042493 IDA:UniProtKBPresponse to drug
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0010043 IEA:EnsemblPresponse to zinc ion
GO:0031295 TAS:ReactomePT cell costimulation
GO:0030217 IMP:UniProtKBPT cell differentiation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0007169 IBA:GO_CentralPtransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032 TAS:ReactomePviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_19238CD28 dependent Vav1 pathway
REACT_12051Cell surface interactions at the vascular wall
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_12623Generation of second messenger molecules
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27283Interleukin-2 signaling
REACT_11068Nef and signal transduction
REACT_11166Nef Mediated CD4 Down-regulation
REACT_11149Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_19324PD-1 signaling
REACT_12519PECAM1 interactions
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_111225Regulation of KIT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_12526TCR signaling
REACT_6835The role of Nef in HIV-1 replication and disease pathogenesis
REACT_12596Translocation of ZAP-70 to Immunological synapse
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