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MGP001806

UniProt Annotations

Entry Information
Gene Namelymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Protein EntryLCP2_HUMAN
UniProt IDQ13094
SpeciesHuman
Comments
Comment typeDescription
DomainThe SH2 domain mediates interaction with SHB.
FunctionInvolved in T-cell antigen receptor mediated signaling.
InteractionP00533:EGFR; NbExp=2; IntAct=EBI-346946, EBI-297353; O15117:FYB; NbExp=5; IntAct=EBI-346946, EBI-1753267; O75791:GRAP2; NbExp=11; IntAct=EBI-346946, EBI-740418; O89100:Grap2 (xeno); NbExp=3; IntAct=EBI-346946, EBI-642151; P62993:GRB2; NbExp=7; IntAct=EBI-346946, EBI-401755; Q8IVH8:MAP4K3; NbExp=5; IntAct=EBI-346946, EBI-1758170; Q99JP0:Map4k3 (xeno); NbExp=2; IntAct=EBI-346946, EBI-5324222; P16333:NCK1; NbExp=14; IntAct=EBI-346946, EBI-389883; P08487:PLCG1 (xeno); NbExp=5; IntAct=EBI-346946, EBI-8013886; P19174:PLCG1; NbExp=3; IntAct=EBI-346946, EBI-79387; Q92783:STAM; NbExp=3; IntAct=EBI-346946, EBI-752333; O75886:STAM2; NbExp=3; IntAct=EBI-346946, EBI-373258; P15498:VAV1; NbExp=9; IntAct=EBI-346946, EBI-625518;
PtmPhosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components. {ECO:0000269|PubMed:15144186, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:18088087, ECO:0000269|PubMed:21725281}.
SimilarityContains 1 SAM (sterile alpha motif) domain. {ECO:0000305}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm {ECO:0000305}.
SubunitInteracts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1. {ECO:0000250, ECO:0000269|PubMed:11301322, ECO:0000269|PubMed:12084069}.
Tissue SpecificityHighly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
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