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MGP001809

UniProt Annotations

Entry Information
Gene Namelactate dehydrogenase B
Protein EntryLDHB_HUMAN
UniProt IDP07195
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(S)-lactate + NAD(+) = pyruvate + NADH.
InteractionQ5S007:LRRK2; NbExp=2; IntAct=EBI-358748, EBI-5323863;
PathwayFermentation; pyruvate fermentation to lactate; (S)- lactate from pyruvate: step 1/1.
PolymorphismRare LDHB variants result in deficiency of lactate dehydrogenase, a condition with no deleterious effects on health. LDHB deficiency is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected. Lactate dehydrogenase deficiency can probably be considered a non-disease [MIM:614128].
SimilarityBelongs to the LDH/MDH superfamily. LDH family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer. {ECO:0000269|PubMed:11276087}.
Web ResourceName=Protein Spotlight; Note=Another dark horse - Issue 109 of September 2009; URL="http://web.expasy.org/spotlight/back_issues/109";
Web ResourceName=Wikipedia; Note=Lactate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Lactate_dehydrogenase";
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