MGP Database

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MGP001813

UniProt Annotations

Entry Information
Gene Namelectin, galactoside-binding, soluble, 3
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionGalactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076}.
InteractionP12763:AHSG (xeno); NbExp=2; IntAct=EBI-1170392, EBI-9396660; Q13740:ALCAM; NbExp=3; IntAct=EBI-1170392, EBI-1188108; P30203:CD6; NbExp=2; IntAct=EBI-1170392, EBI-2873748; Q29983:MICA; NbExp=2; IntAct=EBI-1170392, EBI-1031130;
SimilarityContains 1 galectin domain. {ECO:0000255|PROSITE- ProRule:PRU00639}.
Subcellular LocationCytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.
SubunitProbably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:9501082}.
Tissue SpecificityA major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. {ECO:0000269|PubMed:19497882}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LGALS3ID44396ch14q22.html";
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00118";
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