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MGP001816

UniProt Annotations

Entry Information
Gene Nameligase I, DNA, ATP-dependent
Protein EntryDNLI1_HUMAN
UniProt IDP18858
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P18858-1; Sequence=Displayed; Name=2; IsoId=P18858-2; Sequence=VSP_056139, VSP_056140; Note=No experimental confirmation available.; Name=3; IsoId=P18858-3; Sequence=VSP_057320, VSP_057321; Note=No experimental confirmation available.;
Catalytic ActivityATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). {ECO:0000255|PROSITE- ProRule:PRU10135}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15565146};
FunctionDNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
SimilarityBelongs to the ATP-dependent DNA ligase family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitInteracts with PCNA. {ECO:0000269|PubMed:24911150}.
Web ResourceName=LIG1base; Note=LIG1 mutation db; URL="http://structure.bmc.lu.se/idbase/LIG1base/";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/lig1/";
Web ResourceName=Wikipedia; Note=DNA ligase entry; URL="http://en.wikipedia.org/wiki/DNA_ligase";
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