MGP Database

MGP001831

Record overview

MGPD ID	MGP001831
Gene ID	4015
Species	Homo sapiens (Human)
Gene Name	lysyl oxidase
Gene Symbol	LOX
Alternate names	protein-lysine 6-oxidase;
Chromosome	5
Map Location	5q23.2
EC Number	1.4.3.13
Summary	The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Orthologs	View orthologs and multiple alignments for LOX

Proteins

protein-lysine 6-oxidase isoform 1 preproprotein

Refseq ID:	NP_002308
Protein GI:	20149540
UniProt ID:	P28300
mRNA ID:	NM_002317
Length:	417
RefSeq Status:

MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTA
AARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYR
PGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDI
RYTGHHAYASGCTISPY

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2385
peptide sequence: 
MRFAWTVLLLGPLQLCALVHC

mat_peptide: 169..417
product: protein-lysine 6-oxidase isoform 1
calculated_mol_wt: 29032
peptide sequence: 
DDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQR
VKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITD
VKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

protein-lysine 6-oxidase isoform 2

Refseq ID:	NP_001171573
Protein GI:	296010940
UniProt ID:	B7ZAJ4
mRNA ID:	NM_001178102
Length:	187
RefSeq Status:

`MSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSC DYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2385
peptide sequence: 
MRFAWTVLLLGPLQLCALVHC

mat_peptide: 169..417
product: protein-lysine 6-oxidase isoform 1
calculated_mol_wt: 29032
peptide sequence: 
DDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQR
VKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITD
VKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY