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MGP001831

UniProt Annotations

Entry Information
Gene Namelysyl oxidase
Protein EntryLYOX_HUMAN
UniProt IDP28300
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPeptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2).
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378;
CofactorName=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence={ECO:0000250}; Note=Contains 1 lysine tyrosylquinone. {ECO:0000250};
FunctionResponsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
InteractionO95967:EFEMP2; NbExp=4; IntAct=EBI-3893481, EBI-743414; P15502:ELN; NbExp=2; IntAct=EBI-3893481, EBI-1222108; Q9UBX5:FBLN5; NbExp=2; IntAct=EBI-3893481, EBI-947897; P35555:FBN1; NbExp=2; IntAct=EBI-3893481, EBI-2505934; Q15262:PTPRK; NbExp=4; IntAct=EBI-3893481, EBI-474052;
MiscellaneousThe propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin. {ECO:0000250}.
PtmProteolytically activated by BMP1. {ECO:0000250}.
PtmThe lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
SimilarityBelongs to the lysyl oxidase family. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space.
Tissue SpecificityHeart, placenta, skeletal muscle, kidney, lung and pancreas. {ECO:0000269|PubMed:7706256}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LOXID41191ch5q23.html";
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