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MGP001842

Record overview

MGPD IDMGP001842
Gene ID4051
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 4, subfamily F, polypeptide 3
Gene Symbol CYP4F3
SynonymsCPF3; CYP4F; LTB4H;
Alternate namesdocosahexaenoic acid omega-hydroxylase CYP4F3; 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CYPIVF3; cytochrome P-450; cytochrome P450 4F3; cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); cytochrome P450-LTB-omega; leukotriene B4 omega hydroxylase; leukotriene-B(4) 20-monooxygenase 2; leukotriene-B(4) omega-hydroxylase 2; leukotriene-B4 20-monooxygenase;
Chromosome19
Map Location19p13.2
EC Number1.14.13.199
SummaryThis gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
OrthologsView orthologs and multiple alignments for CYP4F3

Proteins

docosahexaenoic acid omega-hydroxylase CYP4F3 isoform a
Refseq ID:NP_000887
Protein GI:119220562
UniProt ID:Q08477
mRNA ID:NM_000896
Length:520
RefSeq Status:
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVR
IFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTL
DSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR
CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRR
KPELVLRAEGGLWLRVEPLS
 
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform b
Refseq ID:NP_001186137
Protein GI:312836833
UniProt ID:Q08477
mRNA ID:NM_001199208
Length:520
RefSeq Status:
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIR
FCHPNIIRSVINASAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTL
DSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR
CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRR
KPELVLRAEGGLWLRVEPLS
 
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform b
Refseq ID:NP_001186138
Protein GI:312836835
UniProt ID:Q08477
mRNA ID:NM_001199209
Length:520
RefSeq Status:
Protein sequence is identical to GI:312836833 (mRNA isoform)
 
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