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MGP001845

UniProt Annotations

Entry Information
Gene Nameleukotriene C4 synthase
Protein EntryLTC4S_HUMAN
UniProt IDQ16873
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityLeukotriene C(4) = leukotriene A(4) + glutathione.
DiseaseNote=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
FunctionCatalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationNucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomotrimer. Interacts with ALOX5AP and ALOX5. {ECO:0000269|PubMed:17632546, ECO:0000269|PubMed:17632548, ECO:0000269|PubMed:19233132}.
Tissue SpecificityDetected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. {ECO:0000269|PubMed:7599836}.
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