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MGP001850

Record overview

MGPD IDMGP001850
Gene ID4069
SpeciesHomo sapiens (Human)
Gene Namelysozyme
Gene Symbol LYZ
SynonymsLZM;
Alternate nameslysozyme C; 1,4-beta-N-acetylmuramidase C; c-type lysozyme;
Chromosome12
Map Location12q15
EC Number3.2.1.17
SummaryThis gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for LYZ

Proteins

lysozyme C precursor
Refseq ID:NP_000230
Protein GI:4557894
UniProt ID:P61626
mRNA ID:NM_000239
Length:148
RefSeq Status:
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCS
ALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1854
peptide sequence: 
MKALIVLGLVLLSVTVQG

mat_peptide: 19..148
product: lysozyme C
experiment: DESCRIPTION:antibacterial peptide[PMID: 16416029]
calculated_mol_wt: 14701
peptide sequence: 
KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVV
RDPQGIRAWVAWRNRCQNRDVRQYVQGCGV
 
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