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MGP001850

UniProt Annotations

Entry Information
Gene Namelysozyme
Protein EntryLYSC_HUMAN
UniProt IDP61626
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of (1->4)-beta-linkages between N- acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
DiseaseAmyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. {ECO:0000269|PubMed:8464497}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionLysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.
InteractionSelf; NbExp=3; IntAct=EBI-355360, EBI-355360;
MiscellaneousLysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence CautionSequence=CAA32175.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyl hydrolase 22 family. {ECO:0000255|PROSITE-ProRule:PRU00680}.
Subcellular LocationSecreted.
SubunitMonomer.
Web ResourceName=Wikipedia; Note=Lysozyme entry; URL="http://en.wikipedia.org/wiki/Lysozyme";
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