MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001852

UniProt Annotations

Entry Information
Gene Namemyristoylated alanine-rich protein kinase C substrate
Protein EntryMARCS_HUMAN
UniProt IDP29966
SpeciesHuman
Comments
Comment typeDescription
FunctionMARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
PtmPhosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. {ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:8557118}.
SimilarityBelongs to the MARCKS family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000305}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MARCKSID50926ch6q21.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/marcks/";
  logo