MGP Database

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MGP001853

Ontology/Pathway Information

Entrez Gene ID4085
Gene NameMAD2 mitotic arrest deficient-like 1 (yeast)
Gene Symbol MAD2L1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000777 IEA:UniProtKB-SubCellCcondensed chromosome kinetochore
GO:0005829 IDA:UniProtKBCcytosol
GO:0000776 IDA:UniProtKBCkinetochore
GO:0072686 IDA:UniProtKBCmitotic spindle
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0000922 IEA:UniProtKB-SubCellCspindle pole
GO:0042802 IPI:IntActFidentical protein binding
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007093 IDA:UniProtKBPmitotic cell cycle checkpoint
GO:0000070 IEA:EnsemblPmitotic sister chromatid segregation
GO:0007094 TAS:ReactomePmitotic spindle assembly checkpoint
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0060564 IDA:UniProtKBPnegative regulation of mitotic anaphase-promoting complex activity
GO:0045930 IMP:MGIPnegative regulation of mitotic cell cycle
GO:0042177 IDA:UniProtKBPnegative regulation of protein catabolic process
GO:0051436 TAS:ReactomePnegative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0090267 IMP:UniProtKBPpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_795Amplification of signal from the kinetochores
REACT_491Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_267701APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REACT_8017APC-Cdc20 mediated degradation of Nek2A
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_6850Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_1072Inactivation of APC/C via direct inhibition of the APC/C complex
REACT_1041Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
REACT_1275Mitotic Anaphase
REACT_150314Mitotic Metaphase and Anaphase
REACT_682Mitotic Prometaphase
REACT_2137Mitotic Spindle Checkpoint
REACT_910M Phase
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_150471Separation of Sister Chromatids
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