MGP Database

MGP001854

Ontology/Pathway Information

Entrez Gene ID	4086
Gene Name	SMAD family member 1
Gene Symbol	SMAD1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:BHF-UCL	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0016021	NAS:UniProtKB	C	integral component of membrane
GO:0005622	NAS:UniProtKB	C	intracellular
GO:0005637	IDA:UniProtKB	C	nuclear inner membrane
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	NAS:UniProtKB	C	nucleus
GO:0043234	IDA:MGI	C	protein complex
GO:0005667	IEA:Ensembl	C	transcription factor complex
GO:0070410	IPI:BHF-UCL	F	co-SMAD binding
GO:0042802	IPI:BHF-UCL	F	identical protein binding
GO:0070411	IPI:BHF-UCL	F	I-SMAD binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0019901	IPI:UniProtKB	F	protein kinase binding
GO:0005057	NAS:UniProtKB	F	receptor signaling protein activity
GO:0000978	IDA:NTNU_SB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	IDA:NTNU_SB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000979	IEA:Ensembl	F	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	IDA:BHF-UCL	F	sequence-specific DNA binding transcription factor activity
GO:0030618	TAS:BHF-UCL	F	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030509	ISS:UniProtKB	P	BMP signaling pathway
GO:0060348	IEA:Ensembl	P	bone development
GO:0060038	IEA:Ensembl	P	cardiac muscle cell proliferation
GO:0051216	IEA:Ensembl	P	cartilage development
GO:0071773	ISS:BHF-UCL	P	cellular response to BMP stimulus
GO:0009880	ISS:UniProtKB	P	embryonic pattern specification
GO:0007276	IEA:Ensembl	P	gamete generation
GO:0030902	IEA:Ensembl	P	hindbrain development
GO:0042592	IEA:Ensembl	P	homeostatic process
GO:0006954	IEA:Ensembl	P	inflammatory response
GO:0000165	IEA:Ensembl	P	MAPK cascade
GO:0001710	IEA:Ensembl	P	mesodermal cell fate commitment
GO:0030901	IEA:Ensembl	P	midbrain development
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0010656	IEA:Ensembl	P	negative regulation of muscle cell apoptotic process
GO:0002051	IEA:Ensembl	P	osteoblast fate commitment
GO:0061036	IEA:Ensembl	P	positive regulation of cartilage development
GO:0050775	IEA:Ensembl	P	positive regulation of dendrite morphogenesis
GO:0010628	IDA:BHF-UCL	P	positive regulation of gene expression
GO:0045669	IEA:Ensembl	P	positive regulation of osteoblast differentiation
GO:0045944	IDA:NTNU_SB	P	positive regulation of transcription from RNA polymerase II promoter
GO:1901522	ISS:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0031053	TAS:BHF-UCL	P	primary miRNA processing
GO:0006468	IEA:Ensembl	P	protein phosphorylation
GO:0042493	IEA:Ensembl	P	response to drug
GO:0010243	IEA:Ensembl	P	response to organonitrogen compound
GO:0007165	NAS:UniProtKB	P	signal transduction
GO:0007183	IDA:BHF-UCL	P	SMAD protein complex assembly
GO:0007179	NAS:UniProtKB	P	transforming growth factor beta receptor signaling pathway
GO:0001657	IEA:Ensembl	P	ureteric bud development
GO:0042060	IEA:Ensembl	P	wound healing

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_12034	Signaling by BMP
REACT_111102	Signal Transduction