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MGP001894

Record overview

MGPD IDMGP001894
Gene ID4192
SpeciesHomo sapiens (Human)
Gene Namemidkine (neurite growth-promoting factor 2)
Gene Symbol MDK
SynonymsMK; ARAP; NEGF2;
Alternate namesmidkine; amphiregulin-associated protein; midgestation and kidney protein; neurite outgrowth-promoting factor 2; retinoic acid inducible factor;
Chromosome11
Map Location11p11.2
SummaryThis gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
OrthologsView orthologs and multiple alignments for MDK

Proteins

midkine isoform a precursor
Refseq ID:NP_001257479
Protein GI:396080279
UniProt ID:P21741
mRNA ID:NM_001270550
Length:143
RefSeq Status:
MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGT
KVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD
 
midkine isoform a precursor
Refseq ID:NP_001012334
Protein GI:59894792
UniProt ID:P21741
mRNA ID:NM_001012334
Length:143
RefSeq Status:
Protein sequence is identical to GI:396080279 (mRNA isoform)
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..87
product: midkine isoform b
calculated_mol_wt: 7348
peptide sequence: 
VAKKKADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD
 
midkine isoform a precursor
Refseq ID:NP_002382
Protein GI:4505135
UniProt ID:P21741
mRNA ID:NM_002391
Length:143
RefSeq Status:
Protein sequence is identical to GI:396080279 (mRNA isoform)
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD
 
midkine isoform a precursor
Refseq ID:NP_001257480
Protein GI:396080281
UniProt ID:P21741
mRNA ID:NM_001270551
Length:143
RefSeq Status:
Protein sequence is identical to GI:396080279 (mRNA isoform)
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD
 
midkine isoform a precursor
Refseq ID:NP_001012333
Protein GI:59894796
UniProt ID:P21741
mRNA ID:NM_001012333
Length:143
RefSeq Status:
Protein sequence is identical to GI:396080279 (mRNA isoform)
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD
 
midkine isoform b precursor
Refseq ID:NP_001257481
Protein GI:396080285
UniProt ID:P21741
mRNA ID:NM_001270552
Length:87
RefSeq Status:
MQHRGFLLLTLLALLALTSAVAKKKADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..143
product: Midkine
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P21741.1)
calculated_mol_wt: 13421
peptide sequence: 
VAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MQHRGFLLLTLLALLALTSA

mat_peptide: 21..87
product: midkine isoform b
calculated_mol_wt: 7348
peptide sequence: 
VAKKKADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD
 
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