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MGP001894

UniProt Annotations

Entry Information
Gene Namemidkine (neurite growth-promoting factor 2)
Protein EntryMK_HUMAN
UniProt IDP21741
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P21741-1; Sequence=Displayed; Name=2; Synonyms=tMKA; IsoId=P21741-2; Sequence=VSP_047452; Note=Found in cancer tissues with expression in the tumor bodies and surrounding normal cells.;
FunctionDevelopmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.
InductionBy heparin and retinoic acid. {ECO:0000269|PubMed:1768439, ECO:0000269|PubMed:8241100}.
SimilarityBelongs to the pleiotrophin family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer. Interacts with ALK. {ECO:0000269|PubMed:12122009}.
Tissue SpecificityExpressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.
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