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MGP001897

UniProt Annotations

Entry Information
Gene Namemalic enzyme 2, NAD(+)-dependent, mitochondrial
Protein EntryMAOM_HUMAN
UniProt IDP23368
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P23368-1; Sequence=Displayed; Name=2; IsoId=P23368-2; Sequence=VSP_042717; Note=No experimental confirmation available.;
Catalytic ActivityOxaloacetate = pyruvate + CO(2).
Catalytic Activity(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal cations. Prefers magnesium or manganese.;
Enzyme RegulationSubject to allosteric activation by fumarate.
MiscellaneousThis isoenzyme can also use NADP(+) but is more effective with NAD(+).
SimilarityBelongs to the malic enzymes family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer. {ECO:0000269|PubMed:10700286, ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:12962632}.
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