MGP Database

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MGP001903

Ontology/Pathway Information

Entrez Gene ID4214
Gene Namemitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Gene Symbol MAP3K1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008545 IEA:EnsemblFJUN kinase kinase activity
GO:0004709 NAS:UniProtKBFMAP kinase kinase kinase activity
GO:0004672 IDA:MGIFprotein kinase activity
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0030036 IBA:GO_CentralPactin cytoskeleton organization
GO:0000186 IBA:GOCPactivation of MAPKK activity
GO:0008637 IEA:EnsemblPapoptotic mitochondrial changes
GO:0006915 IBA:GO_CentralPapoptotic process
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0003382 IEA:EnsemblPepithelial cell morphogenesis
GO:0061029 IEA:EnsemblPeyelid development in camera-type eye
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 IBA:GO_CentralPintracellular signal transduction
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0030838 IEA:EnsemblPpositive regulation of actin filament polymerization
GO:0006468 NAS:UniProtKBPprotein phosphorylation
GO:0030334 IEA:EnsemblPregulation of cell migration
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0007179 IEA:EnsemblPtransforming growth factor beta receptor signaling pathway
GO:0042060 IEA:EnsemblPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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