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MGP001903

UniProt Annotations

Entry Information
Gene Namemitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Protein EntryM3K1_HUMAN
UniProt IDQ13233
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Disease46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269|PubMed:21129722}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Enzyme RegulationActivated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization.
FunctionComponent of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. {ECO:0000269|PubMed:9808624}.
InteractionP32121:ARRB2; NbExp=2; IntAct=EBI-49776, EBI-714559; P15056:BRAF; NbExp=2; IntAct=EBI-49776, EBI-365980; P61962:DCAF7; NbExp=7; IntAct=EBI-49776, EBI-359808; O75369:FLNB; NbExp=2; IntAct=EBI-49776, EBI-352089; P45985:MAP2K4; NbExp=3; IntAct=EBI-49776, EBI-447868; Q12851:MAP4K2; NbExp=2; IntAct=EBI-49776, EBI-49783; Q12933:TRAF2; NbExp=2; IntAct=EBI-49776, EBI-355744;
PtmAutophosphorylated. {ECO:0000250}.
SimilarityBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 1 SWIM-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00325}.
SubunitBinds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38. {ECO:0000269|PubMed:12223491, ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:9808624}.
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