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MGP001938

Record overview

MGPD IDMGP001938
Gene ID4316
SpeciesHomo sapiens (Human)
Gene Namematrix metallopeptidase 7 (matrilysin, uterine)
Gene Symbol MMP7
SynonymsMMP-7; MPSL1; PUMP-1;
Alternate namesmatrilysin; matrin; matrix metalloproteinase 7 (matrilysin, uterine); matrix metalloproteinase-7; pump-1 protease; uterine matrilysin; uterine metalloproteinase;
Chromosome11
Map Location11q21-q22
EC Number3.4.24.23
SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MMP7

Proteins

matrilysin preproprotein
Refseq ID:NP_002414
Protein GI:4505219
UniProt ID:P09237
mRNA ID:NM_002423
Length:267
RefSeq Status:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPN
SPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTD
GSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1760
peptide sequence: 
MRLTVLCAVCLLPGSLA

mat_peptide: 95..267
product: matrilysin
calculated_mol_wt: 19131
peptide sequence: 
YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDE
DERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
 
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