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MGP001943

UniProt Annotations

Entry Information
Gene Namematrix metallopeptidase 12 (macrophage elastase)
Protein EntryMMP12_HUMAN
UniProt IDP39900
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16- Tyr-|-Leu-17 in the B chain of insulin.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions per subunit.;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
FunctionMay be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
InductionBy exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone.
SimilarityBelongs to the peptidase M10A family. {ECO:0000305}.
SimilarityContains 4 hemopexin repeats. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000305}.
Tissue SpecificityFound in alveolar macrophages but not in peripheral blood monocytes.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp12/";
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