MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001950

UniProt Annotations

Entry Information
Gene NameMNAT CDK-activating kinase assembly factor 1
Protein EntryMAT1_HUMAN
UniProt IDP51948
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51948-1; Sequence=Displayed; Name=2; IsoId=P51948-2; Sequence=VSP_046772;
FunctionStabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 1 UIM (ubiquitin-interacting motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00213}.
Subcellular LocationNucleus.
SubunitAssociates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. {ECO:0000269|PubMed:9852112}.
Tissue SpecificityHighest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mnat1/";
  logo