MGP Database

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MGP001990

Record overview

MGPD IDMGP001990
Gene ID4599
SpeciesHomo sapiens (Human)
Gene NameMX dynamin-like GTPase 1
Gene Symbol MX1
SynonymsMX; MxA; IFI78; IFI-78K;
Alternate namesinterferon-induced GTP-binding protein Mx1; interferon-induced protein p78; interferon-inducible protein p78; interferon-regulated resistance GTP-binding protein MxA; myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78;
Chromosome21
Map Location21q22.3
SummaryThis gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
OrthologsView orthologs and multiple alignments for MX1

Proteins

interferon-induced GTP-binding protein Mx1 isoform a
Refseq ID:NP_002453
Protein GI:222136617
UniProt ID:P20591
mRNA ID:NM_002462
Length:662
RefSeq Status:
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSG
IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKT
LIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK
IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEED
IRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHR
TAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII
QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG
 
interferon-induced GTP-binding protein Mx1 isoform a
Refseq ID:NP_001138397
Protein GI:222136619
UniProt ID:P20591
mRNA ID:NM_001144925
Length:662
RefSeq Status:
Protein sequence is identical to GI:222136617 (mRNA isoform)
 
interferon-induced GTP-binding protein Mx1 isoform a
Refseq ID:NP_001171517
Protein GI:295842578
UniProt ID:P20591
mRNA ID:NM_001178046
Length:662
RefSeq Status:
Protein sequence is identical to GI:222136617 (mRNA isoform)
 
interferon-induced GTP-binding protein Mx1 isoform b
Refseq ID:NP_001269849
Protein GI:544711185
UniProt ID:P20591
mRNA ID:NM_001282920
Length:508
RefSeq Status:
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSG
IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKT
LIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK
IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEED
IRLFTRLRHEFHKWSTIIENNFQEGGQQAHLQPHPFDHPVLHAPDVRPAASEGHAAAPAGQGHLQLAPEGAERHQRQAEVPEGAACTADAGSAPACPVPR
LTTLCPAP
 
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