MGP Database

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MGP001998

Ontology/Pathway Information

Entrez Gene ID4609
Gene Namev-myc avian myelocytomatosis viral oncogene homolog
Gene Symbol MYC
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IDA:UniProtKBCprotein complex
GO:0003677 ISS:UniProtKBFDNA binding
GO:0070888 IDA:UniProtKBFE-box binding
GO:0032403 IDA:UniProtKBFprotein complex binding
GO:0070491 IPI:UniProtKBFrepressing transcription factor binding
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0001658 ISS:UniProtKBPbranching involved in ureteric bud morphogenesis
GO:0060070 IDA:UniProtKBPcanonical Wnt signaling pathway
GO:0007050 IDA:UniProtKBPcell cycle arrest
GO:0006879 IDA:UniProtKBPcellular iron ion homeostasis
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0035690 IDA:UniProtKBPcellular response to drug
GO:0034644 IEP:UniProtKBPcellular response to UV
GO:0006338 IDA:UniProtKBPchromatin remodeling
GO:0051276 IDA:UniProtKBPchromosome organization
GO:0006112 NAS:UniProtKBPenergy reserve metabolic process
GO:0044346 TAS:UniProtKBPfibroblast apoptotic process
GO:0010467 TAS:ReactomePgene expression
GO:0000165 IMP:UniProtKBPMAPK cascade
GO:0043066 ISS:UniProtKBPnegative regulation of apoptotic process
GO:0051782 IDA:UniProtKBPnegative regulation of cell division
GO:0048147 IDA:UniProtKBPnegative regulation of fibroblast proliferation
GO:0045656 IMP:UniProtKBPnegative regulation of monocyte differentiation
GO:0032873 ISS:UniProtKBPnegative regulation of stress-activated MAPK cascade
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0015671 NAS:UniProtKBPoxygen transport
GO:0008284 IDA:MGIPpositive regulation of cell proliferation
GO:0043280 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2000573 IMP:UniProtKBPpositive regulation of DNA biosynthetic process
GO:0050679 IDA:UniProtKBPpositive regulation of epithelial cell proliferation
GO:0048146 IDA:UniProtKBPpositive regulation of fibroblast proliferation
GO:0002053 ISS:UniProtKBPpositive regulation of mesenchymal cell proliferation
GO:0090096 ISS:UniProtKBPpositive regulation of metanephric cap mesenchymal cell proliferation
GO:2001022 IDA:UniProtKBPpositive regulation of response to DNA damage stimulus
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IMP:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0010468 IDA:MGIPregulation of gene expression
GO:0032204 IMP:BHF-UCLPregulation of telomere maintenance
GO:0042493 IEP:UniProtKBPresponse to drug
GO:0010332 IDA:UniProtKBPresponse to gamma radiation
GO:0070848 TAS:UniProtKBPresponse to growth factor
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264532binding of TCF/LEF:CTNNB1 to target gene promoters
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_1574Cyclin E associated events during G1/S transition
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_1783G1/S Transition
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_21267Mitotic G1-G1/S phases
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_899S Phase
REACT_264596TCF dependent signaling in response to WNT
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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