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MGP001998

UniProt Annotations

Entry Information
Gene Namev-myc avian myelocytomatosis viral oncogene homolog
Protein EntryMYC_HUMAN
UniProt IDP01106
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P01106-1; Sequence=Displayed; Name=2; IsoId=P01106-2; Sequence=VSP_037813; Note=Initiates from CTG codon. Ref.7 (BAA01374) sequence is in conflict in positions: 2:D->N, 6:V->E. {ECO:0000305};
BiotechnologyPOU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. {ECO:0000269|PubMed:18035408}.
DiseaseBurkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. {ECO:0000269|PubMed:2166998, ECO:0000269|PubMed:8220424}. Note=The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
DiseaseNote=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
DiseaseNote=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.
FunctionTranscription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes.
InteractionP03070:- (xeno); NbExp=2; IntAct=EBI-447544, EBI-617698; O15169:AXIN1; NbExp=10; IntAct=EBI-447544, EBI-710484; O00499-10:BIN1; NbExp=3; IntAct=EBI-447544, EBI-7689134; O00499-11:BIN1; NbExp=2; IntAct=EBI-447544, EBI-7689211; Q15059:BRD3; NbExp=3; IntAct=EBI-447544, EBI-1383460; Q8N163:CCAR2; NbExp=8; IntAct=EBI-447544, EBI-355410; P11802:CDK4; NbExp=2; IntAct=EBI-447544, EBI-295644; Q86XR8:CEP57; NbExp=3; IntAct=EBI-447544, EBI-308614; Q14839:CHD4; NbExp=2; IntAct=EBI-447544, EBI-372916; O15111:CHUK; NbExp=3; IntAct=EBI-447544, EBI-81249; P03129:E7 (xeno); NbExp=2; IntAct=EBI-447544, EBI-866453; P04020:E7 (xeno); NbExp=2; IntAct=EBI-447544, EBI-7005254; P06788:E7 (xeno); NbExp=5; IntAct=EBI-447544, EBI-1776887; Q15029:EFTUD2; NbExp=5; IntAct=EBI-447544, EBI-357897; Q969H0:FBXW7; NbExp=4; IntAct=EBI-447544, EBI-359574; Q8N3Y1:FBXW8; NbExp=3; IntAct=EBI-447544, EBI-914770; Q92769:HDAC2; NbExp=2; IntAct=EBI-447544, EBI-301821; O15379:HDAC3; NbExp=6; IntAct=EBI-447544, EBI-607682; Q9Y6K9:IKBKG; NbExp=3; IntAct=EBI-447544, EBI-81279; Q8TCG1:KIAA1524; NbExp=2; IntAct=EBI-447544, EBI-1379376; P61244:MAX; NbExp=21; IntAct=EBI-447544, EBI-751711; P52164:Max (xeno); NbExp=4; IntAct=EBI-447544, EBI-1184963; P33993:MCM7; NbExp=6; IntAct=EBI-447544, EBI-355924; O75928:PIAS2; NbExp=4; IntAct=EBI-447544, EBI-348555; P62913:RPL11; NbExp=3; IntAct=EBI-447544, EBI-354380; Q96EB6:SIRT1; NbExp=4; IntAct=EBI-447544, EBI-1802965; Q8N6T7:SIRT6; NbExp=3; IntAct=EBI-447544, EBI-712415; Q13309:SKP2; NbExp=2; IntAct=EBI-447544, EBI-456291; Q8TAD8:SNIP1; NbExp=9; IntAct=EBI-447544, EBI-749336; P08047:SP1; NbExp=4; IntAct=EBI-447544, EBI-298336; P11387:TOP1; NbExp=2; IntAct=EBI-447544, EBI-876302; Q9Y4A5:TRRAP; NbExp=4; IntAct=EBI-447544, EBI-399128; P0CG48:UBC; NbExp=5; IntAct=EBI-447544, EBI-3390054; P17480:UBTF; NbExp=2; IntAct=EBI-447544, EBI-396235; Q13105:ZBTB17; NbExp=4; IntAct=EBI-447544, EBI-372156;
PtmPhosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. {ECO:0000250, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20713526, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:8386367}.
PtmUbiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. {ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20713526, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:8386367}.
SimilarityContains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}.
Subcellular LocationNucleus, nucleoplasm {ECO:0000269|PubMed:17558397}. Nucleus, nucleolus {ECO:0000269|PubMed:17558397}.
SubunitEfficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. {ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:15674325, ECO:0000269|PubMed:15723054, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:17311883, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:9680483}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYCID27.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/myc/";
Web ResourceName=Wikipedia; Note=Myc entry; URL="http://en.wikipedia.org/wiki/Myc";
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