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MGP002064

UniProt Annotations

Entry Information

Gene Name	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
Protein Entry	NDUS3_HUMAN
UniProt ID	O75489
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75489-1; Sequence=Displayed; Name=2; IsoId=O75489-2; Sequence=VSP_057065, VSP_057066; Note=No experimental confirmation available.;
Catalytic Activity	NADH + acceptor = NAD(+) + reduced acceptor.
Catalytic Activity	NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Interaction	O75306:NDUFS2; NbExp=5; IntAct=EBI-1224896, EBI-1224806;
Similarity	Belongs to the complex I 30 kDa subunit family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane.
Subunit	Mammalian complex I is composed of 45 different subunits. Interacts with NDUFAF3. {ECO:0000269\|PubMed:12611891, ECO:0000269\|PubMed:19463981}.