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MGP002077

Ontology/Pathway Information

Entrez Gene ID4751
Gene NameNIMA-related kinase 2
Gene Symbol NEK2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:UniProtKBCcentrosome
GO:0000777 IEA:UniProtKB-SubCellCcondensed chromosome kinetochore
GO:0000794 IEA:EnsemblCcondensed nuclear chromosome
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0045171 IDA:HPACintercellular bridge
GO:0000776 IDA:UniProtKBCkinetochore
GO:0005874 IEA:UniProtKB-KWCmicrotubule
GO:0030496 IEA:EnsemblCmidbody
GO:0005730 IEA:UniProtKB-SubCellCnucleolus
GO:0005634 IDA:HPACnucleus
GO:0043234 IMP:UniProtKBCprotein complex
GO:0000922 IEA:UniProtKB-SubCellCspindle pole
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0004674 TAS:UniProtKBFprotein serine/threonine kinase activity
GO:0001824 IEA:EnsemblPblastocyst development
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0051299 IDA:UniProtKBPcentrosome separation
GO:0007059 IDA:UniProtKBPchromosome segregation
GO:0000086 TAS:ReactomePG2/M transition of mitotic cell cycle
GO:0051321 IEA:UniProtKB-KWPmeiotic cell cycle
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007067 TAS:ProtIncPmitotic nuclear division
GO:0000070 IEA:EnsemblPmitotic sister chromatid segregation
GO:1903126 IMP:UniProtKBPnegative regulation of centriole-centriole cohesion
GO:0043392 IEA:EnsemblPnegative regulation of DNA binding
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0051988 IMP:UniProtKBPregulation of attachment of spindle microtubules to kinetochore
GO:0007088 TAS:ProtIncPregulation of mitosis
GO:0046602 TAS:UniProtKBPregulation of mitotic centrosome separation
GO:0051225 TAS:UniProtKBPspindle assembly
GO:0090307 IEA:EnsemblPspindle assembly involved in mitosis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_267965Anchoring of the basal body to the plasma membrane
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_267701APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REACT_8017APC-Cdc20 mediated degradation of Nek2A
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_268265Assembly of the primary cilium
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_15479Centrosome maturation
REACT_2203G2/M Transition
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization from the centrosome
REACT_21391Mitotic G2-G2/M phases
REACT_264135Organelle biogenesis and maintenance
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_21279Regulation of mitotic cell cycle
REACT_160315Regulation of PLK1 Activity at G2/M Transition
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