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MGP002090

Record overview

MGPD IDMGP002090
Gene ID4792
SpeciesHomo sapiens (Human)
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Symbol NFKBIA
SynonymsIKBA; MAD-3; NFKBI;
Alternate namesNF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkappaBalpha; ikB-alpha; major histocompatibility complex enhancer-binding protein MAD3; nuclear factor of kappa light chain gene enhancer in B-cells;
Chromosome14
Map Location14q13
SummaryThis gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for NFKBIA

Proteins

NF-kappa-B inhibitor alpha
Refseq ID:NP_065390
Protein GI:10092619
UniProt ID:P25963
mRNA ID:NM_020529
Length:317
RefSeq Status:
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGD
LAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVE
LLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
DELPYDDCVFGGQRLTL
 
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