MGP Database

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MGP002090

Ontology/Pathway Information

Entrez Gene ID4792
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Symbol NFKBIA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0033256 TAS:BHF-UCLCI-kappaB/NF-kappaB complex
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:HPACplasma membrane
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0051059 IPI:UniProtKBFNF-kappaB binding
GO:0008139 IPI:UniProtKBFnuclear localization sequence binding
GO:0008134 TAS:ProtIncFtranscription factor binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0006915 TAS:ProtIncPapoptotic process
GO:0070417 NAS:BHF-UCLPcellular response to cold
GO:0007253 IMP:BHF-UCLPcytoplasmic sequestering of NF-kappaB
GO:0042994 IDA:UniProtKBPcytoplasmic sequestering of transcription factor
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0043066 TAS:ReactomePnegative regulation of apoptotic process
GO:0043392 NAS:UniProtKBPnegative regulation of DNA binding
GO:0010888 IMP:BHF-UCLPnegative regulation of lipid storage
GO:0010745 IMP:BHF-UCLPnegative regulation of macrophage derived foam cell differentiation
GO:0045638 IEA:EnsemblPnegative regulation of myeloid cell differentiation
GO:0032088 IDA:MGIPnegative regulation of NF-kappaB transcription factor activity
GO:0045746 IEA:EnsemblPnegative regulation of Notch signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0070427 IEA:EnsemblPnucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 IEA:EnsemblPnucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0032270 IMP:BHF-UCLPpositive regulation of cellular protein metabolic process
GO:0010875 IMP:BHF-UCLPpositive regulation of cholesterol efflux
GO:0051092 TAS:ReactomePpositive regulation of NF-kappaB transcription factor activity
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0000060 IEA:EnsemblPprotein import into nucleus, translocation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0042345 NAS:UniProtKBPregulation of NF-kappaB import into nucleus
GO:0043330 IEA:EnsemblPresponse to exogenous dsRNA
GO:0032495 IEA:EnsemblPresponse to muramyl dipeptide
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_13696NF-kB is activated and signals survival
REACT_13776p75 NTR receptor-mediated signalling
REACT_13537p75NTR signals via NF-kB
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_12526TCR signaling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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