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MGP002091

Record overview

MGPD IDMGP002091
Gene ID4793
SpeciesHomo sapiens (Human)
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Gene Symbol NFKBIB
SynonymsIKBB; TRIP9;
Alternate namesNF-kappa-B inhibitor beta; I-kappa-B-beta; NF-kappa-BIB; TR-interacting protein 9; TRIP-9; ikB-B; ikB-beta; ikappaBbeta; thyroid receptor-interacting protein 9;
Chromosome19
Map Location19q13.1
SummaryThe protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
OrthologsView orthologs and multiple alignments for NFKBIB

Proteins

NF-kappa-B inhibitor beta isoform 1
Refseq ID:NP_002494
Protein GI:21361135
UniProt ID:Q15653
mRNA ID:NM_002503
Length:356
RefSeq Status:
MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHL
AAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL
EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE
PEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV
 
NF-kappa-B inhibitor beta isoform 2
Refseq ID:NP_001230045
Protein GI:340805857
UniProt ID:Q15653
mRNA ID:NM_001243116
Length:270
RefSeq Status:
MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLE
KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN
PILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV
 
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