MGP Database

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MGP002091

Ontology/Pathway Information

Entrez Gene ID4793
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Gene Symbol NFKBIB
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0004871 TAS:ProtIncFsignal transducer activity
GO:0003713 TAS:ProtIncFtranscription coactivator activity
GO:0045087 TAS:ReactomePinnate immune response
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0051092 TAS:ReactomePpositive regulation of NF-kappaB transcription factor activity
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0007165 TAS:ProtIncPsignal transduction
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006351 TAS:ProtIncPtranscription, DNA-templated
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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