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MGP002092

UniProt Annotations

Entry Information
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Protein EntryIKBE_HUMAN
UniProt IDO00221
SpeciesHuman
Comments
Comment typeDescription
FunctionInhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}.
InteractionQ8IWZ3:ANKHD1; NbExp=2; IntAct=EBI-355098, EBI-359558; Q9UPN7:PPP6R1; NbExp=2; IntAct=EBI-355098, EBI-359745; O75170:PPP6R2; NbExp=2; IntAct=EBI-355098, EBI-359739;
PtmSerine phosphorylated; followed by proteasome-dependent degradation.
Sequence CautionSequence=AAC51216.1; Type=Frameshift; Positions=339, 351; Evidence={ECO:0000305};
SimilarityBelongs to the NF-kappa-B inhibitor family. {ECO:0000305}.
SimilarityContains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitInteracts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. {ECO:0000269|PubMed:9315679}.
Tissue SpecificityHighly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
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