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MGP002104

Record overview

MGPD IDMGP002104
Gene ID4830
SpeciesHomo sapiens (Human)
Gene NameNME/NM23 nucleoside diphosphate kinase 1
Gene Symbol NME1
SynonymsNB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1;
Alternate namesnucleoside diphosphate kinase A; NDP kinase A; granzyme A-activated DNase; metastasis inhibition factor nm23; non-metastatic cells 1, protein (NM23A) expressed in; tumor metastatic process-associated protein;
Chromosome17
Map Location17q21.3
EC Number2.7.4.6
SummaryThis gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for NME1

Proteins

nucleoside diphosphate kinase A isoform a
Refseq ID:NP_937818
Protein GI:38045913
UniProt ID:P15531
mRNA ID:NM_198175
Length:177
RefSeq Status:
MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
 
nucleoside diphosphate kinase A isoform b
Refseq ID:NP_000260
Protein GI:4557797
UniProt ID:P15531
mRNA ID:NM_000269
Length:152
RefSeq Status:
MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSK
PGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
 
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