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MGP002106

Record overview

MGPD IDMGP002106
Gene ID4833
SpeciesHomo sapiens (Human)
Gene NameNME/NM23 nucleoside diphosphate kinase 4
Gene Symbol NME4
SynonymsNDPK-D; NM23H4; nm23-H4;
Alternate namesnucleoside diphosphate kinase, mitochondrial; NDK; NDP kinase D; NDP kinase, mitochondrial; NDPKD; non-metastatic cells 4, protein expressed in; nucleoside diphosphate kinase D;
Chromosome16
Map Location16p13.3
EC Number2.7.4.6
SummaryThe nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
OrthologsView orthologs and multiple alignments for NME4

Proteins

nucleoside diphosphate kinase, mitochondrial isoform a precursor
Refseq ID:NP_005000
Protein GI:4826862
UniProt ID:O00746
mRNA ID:NM_005009
Length:187
RefSeq Status:
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRY
MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
nucleoside diphosphate kinase, mitochondrial isoform b
Refseq ID:NP_001273362
Protein GI:556695376
UniProt ID:O00746
mRNA ID:NM_001286433
Length:153
RefSeq Status:
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQVWEGYNVVRASRAMIGHTDSAEAAP
GTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
nucleoside diphosphate kinase, mitochondrial isoform c
Refseq ID:NP_001273364
Protein GI:556695465
UniProt ID:O00746
mRNA ID:NM_001286435
Length:173
RefSeq Status:
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRY
MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISSHRLAPLDRGQREQQMVPGIPQGAHEA
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
nucleoside diphosphate kinase, mitochondrial isoform d
Refseq ID:NP_001273365
Protein GI:556695383
UniProt ID:O00746
mRNA ID:NM_001286436
Length:117
RefSeq Status:
MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSS
ELVSWADGGQHSSIHPA
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
nucleoside diphosphate kinase, mitochondrial isoform d
Refseq ID:NP_001273368
Protein GI:556695432
UniProt ID:O00746
mRNA ID:NM_001286439
Length:117
RefSeq Status:
Protein sequence is identical to GI:556695383 (mRNA isoform)
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
nucleoside diphosphate kinase, mitochondrial isoform d
Refseq ID:NP_001273369
Protein GI:556695397
UniProt ID:O00746
mRNA ID:NM_001286440
Length:117
RefSeq Status:
Protein sequence is identical to GI:556695383 (mRNA isoform)
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
nucleoside diphosphate kinase, mitochondrial isoform d
Refseq ID:NP_001273367
Protein GI:556695391
UniProt ID:O00746
mRNA ID:NM_001286438
Length:117
RefSeq Status:
Protein sequence is identical to GI:556695383 (mRNA isoform)
 
transit_peptide: 1..33
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 3417
peptide sequence: 
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGP

mat_peptide: 34..187
product: Nucleoside diphosphate kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O00746.1)
calculated_mol_wt: 17260
peptide sequence: 
SWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA
PGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA
 
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