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MGP002106

UniProt Annotations

Entry Information
Gene NameNME/NM23 nucleoside diphosphate kinase 4
Protein EntryNDKM_HUMAN
UniProt IDO00746
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00746-1; Sequence=Displayed; Name=2; IsoId=O00746-2; Sequence=VSP_054743; Note=No experimental confirmation available. Gene prediction based on EST data.;
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionMajor role in the synthesis of nucleoside triphosphates other than ATP. {ECO:0000250}.
InteractionP42858:HTT; NbExp=2; IntAct=EBI-744871, EBI-466029;
SimilarityBelongs to the NDK family. {ECO:0000305}.
Subcellular LocationMitochondrion intermembrane space.
SubunitHomohexamer. Interacts with CAPN8 (By similarity). {ECO:0000250}.
Tissue SpecificityWidely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.
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