MGP Database

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MGP002110

Ontology/Pathway Information

Entrez Gene ID4842
Gene Namenitric oxide synthase 1 (neuronal)
Gene Symbol NOS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:BHF-UCLCcytoplasm
GO:0005856 ISS:BHF-UCLCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0043197 IEA:UniProtKB-SubCellCdendritic spine
GO:0045121 ISS:BHF-UCLCmembrane raft
GO:0005739 ISS:BHF-UCLCmitochondrion
GO:0048471 ISS:BHF-UCLCperinuclear region of cytoplasm
GO:0001917 ISS:BHF-UCLCphotoreceptor inner segment
GO:0043234 ISS:BHF-UCLCprotein complex
GO:0042383 IDA:BHF-UCLCsarcolemma
GO:0016529 IDA:BHF-UCLCsarcoplasmic reticulum
GO:0045202 ISS:BHF-UCLCsynapse
GO:0034618 TAS:BHF-UCLFarginine binding
GO:0046870 ISS:BHF-UCLFcadmium ion binding
GO:0050660 ISS:BHF-UCLFflavin adenine dinucleotide binding
GO:0010181 ISS:BHF-UCLFFMN binding
GO:0020037 ISS:BHF-UCLFheme binding
GO:0044325 ISS:BHF-UCLFion channel binding
GO:0005506 IEA:InterProFiron ion binding
GO:0050661 ISS:BHF-UCLFNADP binding
GO:0003958 IBA:GO_CentralFNADPH-hemoprotein reductase activity
GO:0004517 ISS:BHF-UCLFnitric-oxide synthase activity
GO:0016491 IBA:GO_CentralFoxidoreductase activity
GO:0097110 ISS:BHF-UCLFscaffold protein binding
GO:0017080 ISS:BHF-UCLFsodium channel regulator activity
GO:0034617 NAS:BHF-UCLFtetrahydrobiopterin binding
GO:0006527 IC:BHF-UCLParginine catabolic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0071363 ISS:BHF-UCLPcellular response to growth factor stimulus
GO:0042738 ISS:BHF-UCLPexogenous drug catabolic process
GO:0051701 TAS:ReactomePinteraction with host
GO:0033555 IMP:BHF-UCLPmulticellular organismal response to stress
GO:0007520 TAS:BHF-UCLPmyoblast fusion
GO:0045776 IBA:GO_CentralPnegative regulation of blood pressure
GO:0051926 ISS:BHF-UCLPnegative regulation of calcium ion transport
GO:0010523 TAS:BHF-UCLPnegative regulation of calcium ion transport into cytosol
GO:0051346 ISS:BHF-UCLPnegative regulation of hydrolase activity
GO:0043267 ISS:BHF-UCLPnegative regulation of potassium ion transport
GO:0051612 ISS:BHF-UCLPnegative regulation of serotonin uptake
GO:0042136 TAS:BHF-UCLPneurotransmitter biosynthetic process
GO:0006809 ISS:BHF-UCLPnitric oxide biosynthetic process
GO:0007263 IBA:GO_CentralPnitric oxide mediated signal transduction
GO:0018119 ISS:BHF-UCLPpeptidyl-cysteine S-nitrosylation
GO:0090382 TAS:ReactomePphagosome maturation
GO:0031284 IBA:GO_CentralPpositive regulation of guanylate cyclase activity
GO:0035066 ISS:BHF-UCLPpositive regulation of histone acetylation
GO:1902307 ISS:BHF-UCLPpositive regulation of sodium ion transmembrane transport
GO:0098735 ISS:BHF-UCLPpositive regulation of the force of heart contraction
GO:0045893 ISS:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0045909 IDA:BHF-UCLPpositive regulation of vasodilation
GO:0055117 TAS:BHF-UCLPregulation of cardiac muscle contraction
GO:0002028 ISS:BHF-UCLPregulation of sodium ion transport
GO:0009408 IDA:BHF-UCLPresponse to heat
GO:0001666 IEP:BHF-UCLPresponse to hypoxia
GO:0006941 ISS:BHF-UCLPstriated muscle contraction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_604Hemostasis
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_23876Platelet homeostasis
SMP Pathway Links
SMP IDDescription
SMP00020Arginine and Proline Metabolism
SMP00362Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
SMP00504Creatine deficiency, guanidinoacetate methyltransferase deficiency
SMP00188Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
SMP00506Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
SMP00505Hyperornithinemia with gyrate atrophy (HOGA)
SMP00361Hyperprolinemia Type I
SMP00360Hyperprolinemia Type II
SMP00507L-arginine:glycine amidinotransferase deficiency
SMP00363Ornithine Aminotransferase Deficiency (OAT Deficiency)
SMP00207Prolidase Deficiency (PD)
SMP00208Prolinemia Type II
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