MGP Database

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MGP002111

Ontology/Pathway Information

Entrez Gene ID4843
Gene Namenitric oxide synthase 2, inducible
Gene Symbol NOS2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030863 IEA:EnsemblCcortical cytoskeleton
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IMP:BHF-UCLCcytosol
GO:0005622 IDA:BHF-UCLCintracellular
GO:0005634 ISS:BHF-UCLCnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005777 IDA:UniProtKBCperoxisome
GO:0034618 ISS:BHF-UCLFarginine binding
GO:0050660 ISS:BHF-UCLFflavin adenine dinucleotide binding
GO:0010181 ISS:BHF-UCLFFMN binding
GO:0020037 ISS:BHF-UCLFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0050661 TAS:BHF-UCLFNADP binding
GO:0003958 IBA:GO_CentralFNADPH-hemoprotein reductase activity
GO:0004517 IDA:UniProtKBFnitric-oxide synthase activity
GO:0042803 ISS:BHF-UCLFprotein homodimerization activity
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0034617 ISS:BHF-UCLFtetrahydrobiopterin binding
GO:0006527 IDA:BHF-UCLParginine catabolic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0071346 IEA:EnsemblPcellular response to interferon-gamma
GO:0071222 IEA:EnsemblPcellular response to lipopolysaccharide
GO:0007623 IEA:EnsemblPcircadian rhythm
GO:0042742 ISS:UniProtKBPdefense response to bacterium
GO:0050829 NAS:BHF-UCLPdefense response to Gram-negative bacterium
GO:0006954 IBA:GO_CentralPinflammatory response
GO:0002227 NAS:BHF-UCLPinnate immune response in mucosa
GO:0051701 TAS:ReactomePinteraction with host
GO:0045776 IBA:GO_CentralPnegative regulation of blood pressure
GO:0010629 IGI:UniProtKBPnegative regulation of gene expression
GO:0042177 IEA:EnsemblPnegative regulation of protein catabolic process
GO:0006809 IDA:UniProtKBPnitric oxide biosynthetic process
GO:0007263 IBA:GO_CentralPnitric oxide mediated signal transduction
GO:0018119 ISS:UniProtKBPpeptidyl-cysteine S-nitrosylation
GO:0090382 TAS:ReactomePphagosome maturation
GO:0031284 IBA:GO_CentralPpositive regulation of guanylate cyclase activity
GO:0051712 IMP:BHF-UCLPpositive regulation of killing of cells of other organism
GO:0001912 TAS:BHF-UCLPpositive regulation of leukocyte mediated cytotoxicity
GO:0045909 IBA:GO_CentralPpositive regulation of vasodilation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0043457 TAS:BHF-UCLPregulation of cellular respiration
GO:0050796 IMP:BHF-UCLPregulation of insulin secretion
GO:0009617 NAS:UniProtKBPresponse to bacterium
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0006801 ISS:UniProtKBPsuperoxide metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_604Hemostasis
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_23876Platelet homeostasis
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