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MGP002124

Record overview

MGPD IDMGP002124
Gene ID4869
SpeciesHomo sapiens (Human)
Gene Namenucleophosmin (nucleolar phosphoprotein B23, numatrin)
Gene Symbol NPM1
SynonymsB23; NPM;
Alternate namesnucleophosmin; nucleolar protein NO38; nucleophosmin/nucleoplasmin family, member 1;
Chromosome5
Map Location5q35.1
SummaryThis gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
OrthologsView orthologs and multiple alignments for NPM1

Proteins

nucleophosmin isoform 1
Refseq ID:NP_002511
Protein GI:10835063
UniProt ID:P06748
mRNA ID:NM_002520
Length:294
RefSeq Status:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVL
RLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTP
AKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
 
nucleophosmin isoform 2
Refseq ID:NP_954654
Protein GI:40353734
UniProt ID:P06748
mRNA ID:NM_199185
Length:265
RefSeq Status:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVL
RLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFK
KQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
 
nucleophosmin isoform 3
Refseq ID:NP_001032827
Protein GI:83641870
UniProt ID:P06748
mRNA ID:NM_001037738
Length:259
RefSeq Status:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVL
RLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTP
AKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKAH
 
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