MGP Database

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MGP002129

Record overview

MGPD IDMGP002129
Gene ID4891
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Gene Symbol SLC11A2
SynonymsDCT1; DMT1; NRAMP2;
Alternate namesnatural resistance-associated macrophage protein 2; DMT-1; NRAMP 2; divalent cation transporter 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; solute carrier family 11 member 2;
Chromosome12
Map Location12q13
SummaryThis gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
OrthologsView orthologs and multiple alignments for SLC11A2

Proteins

natural resistance-associated macrophage protein 2 isoform 1
Refseq ID:NP_001167596
Protein GI:295293167
UniProt ID:P49281
mRNA ID:NM_001174125
Length:590
RefSeq Status:
MRKKQLKTEAAPHCELKSYSKNSATQVSTMVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLW
AFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIA
INLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYL
HSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAA
LYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFA
NGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK
 
natural resistance-associated macrophage protein 2 isoform 2
Refseq ID:NP_001167597
Protein GI:295293169
UniProt ID:P49281
mRNA ID:NM_001174126
Length:568
RefSeq Status:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVA
GFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLD
KYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES
CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEG
FLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVR
DLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
 
natural resistance-associated macrophage protein 2 isoform 2
Refseq ID:NP_001167598
Protein GI:295293171
UniProt ID:P49281
mRNA ID:NM_001174127
Length:568
RefSeq Status:
Protein sequence is identical to GI:295293169 (mRNA isoform)
 
natural resistance-associated macrophage protein 2 isoform 3
Refseq ID:NP_000608
Protein GI:10835169
UniProt ID:P49281
mRNA ID:NM_000617
Length:561
RefSeq Status:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVA
GFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLD
KYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES
CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEG
FLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVR
DLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK
 
natural resistance-associated macrophage protein 2 isoform 3
Refseq ID:NP_001167600
Protein GI:295293173
UniProt ID:P49281
mRNA ID:NM_001174129
Length:561
RefSeq Status:
Protein sequence is identical to GI:10835169 (mRNA isoform)
 
natural resistance-associated macrophage protein 2 isoform 3
Refseq ID:NP_001167599
Protein GI:295293175
UniProt ID:P49281
mRNA ID:NM_001174128
Length:561
RefSeq Status:
Protein sequence is identical to GI:10835169 (mRNA isoform)
 
natural resistance-associated macrophage protein 2 isoform 4
Refseq ID:NP_001167601
Protein GI:295293178
UniProt ID:P49281
mRNA ID:NM_001174130
Length:557
RefSeq Status:
MSTVDYLNSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKL
LWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGL
RKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIAL
FVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNL
KWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGH
VALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEEATRGYVK
 
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