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MGP002147

Record overview

MGPD IDMGP002147
Gene ID4929
SpeciesHomo sapiens (Human)
Gene Namenuclear receptor subfamily 4, group A, member 2
Gene Symbol NR4A2
SynonymsNOT; RNR1; HZF-3; NURR1; TINUR;
Alternate namesnuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor;
Chromosome2
Map Location2q22-q23
SummaryThis gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for NR4A2

Proteins

nuclear receptor subfamily 4 group A member 2
Refseq ID:NP_006177
Protein GI:5453822
UniProt ID:P43354
mRNA ID:NM_006186
Length:598
RefSeq Status:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNY
QQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHV
PMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCL
ANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDT
QHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDI
SAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
 
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