MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002147

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 4, group A, member 2
Protein EntryNR4A2_HUMAN
UniProt IDP43354
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43354-1; Sequence=Displayed; Name=2; IsoId=P43354-2; Sequence=VSP_056057;
Developmental StageRapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.
Domainthe ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125). {ECO:0000269|PubMed:12774125}.
FunctionTranscriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250}.
InteractionQ5H9L2:TCEAL5; NbExp=2; IntAct=EBI-2681738, EBI-2681773;
SimilarityBelongs to the nuclear hormone receptor family. NR4 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationCytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.
SubunitInteracts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
  logo