MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002152

Record overview

MGPD IDMGP002152
Gene ID4953
SpeciesHomo sapiens (Human)
Gene Nameornithine decarboxylase 1
Gene Symbol ODC1
SynonymsODC;
Alternate namesornithine decarboxylase;
Chromosome2
Map Location2p25
EC Number4.1.1.17;
SummaryThis gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
OrthologsView orthologs and multiple alignments for ODC1

Proteins

ornithine decarboxylase isoform 1
Refseq ID:NP_002530
Protein GI:4505489
UniProt ID:P11926
mRNA ID:NM_002539
Length:461
RefSeq Status:
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQS
LGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGS
GCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ
TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGF
QRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
 
ornithine decarboxylase isoform 1
Refseq ID:NP_001274118
Protein GI:563580287
UniProt ID:P11926
mRNA ID:NM_001287189
Length:461
RefSeq Status:
Protein sequence is identical to GI:4505489 (mRNA isoform)
 
ornithine decarboxylase isoform 1
Refseq ID:NP_001274119
Protein GI:563580289
UniProt ID:P11926
mRNA ID:NM_001287190
Length:461
RefSeq Status:
Protein sequence is identical to GI:4505489 (mRNA isoform)
 
ornithine decarboxylase isoform 2
Refseq ID:NP_001274117
Protein GI:563580285
UniProt ID:B4DXF8
mRNA ID:NM_001287188
Length:332
RefSeq Status:
MMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSM
YLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCI
LYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEV
EEQDASTLPVSCAWESGMKRHRAACASASINV
 
  logo